Suchergebnisse - ((program OR (program OR (program OR program))) OR (program OR (progress OR programu)))

Dengue Therapeutics, Chemoprophylaxis, and Allied Tools: State of the Art and Future Directions von Simmons, Cameron

“… Whilst drug discovery efforts gestate, there are ongoing clinical research designed to benefit today's patients, including trials of supportive care interventions, and descriptive studies that should improve the ability of clinicians to make an accurate diagnosis early in the illness course and to identify patients most at risk of progression to severe disease. This review provides a state of the art summary of dengue drug discovery, clinical trials, and supportive allied research and reflects discussions at the 2nd International Dengue Therapeutics Workshop held in Ho Chi Minh City, Vietnam, in December 2013. …”
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Relationship between Mycobacterium tuberculosis genotype and the clinical phenotype of pulmonary and meningeal tuberculosis von Simmons, Cameron

“… The association between the East Asian/Beijing lineage and disease progression and CSF leukocyte count suggests the lineage may alter the presentation of meningitis by influencing the intracerebral inflammatory response.  …”
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A Prognostic Model for Development of Profound Shock among Children Presenting with Dengue Shock Syndrome von Simmons, Cameron

“… RESULTS: The analysis population included 1207 children of whom 222 (18%) progressed to "profound DSS" and 433 (36%) had recurrent shock.  …”
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Lovastatin for the Treatment of Adult Patients With Dengue: A Randomized, Double-Blind, Placebo-Controlled Trial von Simmons, Cameron

“… Secondary outcomes included comparisons of disease progression rates, fever clearance times, and measures of plasma viremia and quality of life between the treatment arms.  …”
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Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries von Simmons, Cameron

“… Additionally, among patients with confirmed dengue we aim to identify simple clinical and laboratory parameters associated with progression to a more severe disease course. We will also investigate early virological and serological correlates of severe disease, and examine genetic associations in this large heterogeneous cohort.  …”
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