The epidemiology and aetiology of diarrhoeal disease in infancy in southern Vietnam: a birth cohort study
OBJECTIVES: Previous studies indicate a high burden of diarrhoeal disease in Vietnamese children, however longitudinal community-based data on burden and aetiology are limited. The findings from a large, prospective cohort study of diarrhoeal disease in infants in southern Vietnam are presented here...
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| Natura: | Journal Article |
| Lingua: | inglese |
| Pubblicazione: |
2018
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| Accesso online: | https://demo7.dspace.org/handle/123456789/138 |
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| _version_ | 1860822454932340737 |
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| author | Simmons, Cameron |
| author_browse | Simmons, Cameron |
| author_facet | Simmons, Cameron |
| author_sort | Simmons, Cameron |
| collection | DSpace |
| description | OBJECTIVES: Previous studies indicate a high burden of diarrhoeal disease in Vietnamese children, however longitudinal community-based data on burden and aetiology are limited. The findings from a large, prospective cohort study of diarrhoeal disease in infants in southern Vietnam are presented herein. METHODS: Infants were enrolled at birth in urban Ho Chi Minh City and a semi-rural district in southern Vietnam, and followed for 12 months (n=6706). Diarrhoeal illness episodes were identified through clinic-based passive surveillance, hospital admissions, and self-reports. RESULTS: The minimum incidence of diarrhoeal illness in the first year of life was 271/1000 infant-years of observation for the whole cohort. Rotavirus was the most commonly detected pathogen (50% of positive samples), followed by norovirus (24%), Campylobacter (20%), Salmonella (18%), and Shigella (16%). Repeat infections were identified in 9% of infants infected with rotavirus, norovirus, Shigella, or Campylobacter, and 13% of those with Salmonella infections. CONCLUSIONS: The minimum incidence of diarrhoeal disease in infants in both urban and semi-rural settings in southern Vietnam was quantified prospectively. A large proportion of laboratory-diagnosed disease was caused by rotavirus and norovirus. These data highlight the unmet need for a rotavirus vaccine in Vietnam and provide evidence of the previously unrecognized burden of norovirus in infants. |
| format | Journal Article |
| id | oai:localhost:123456789-138 |
| institution | DSPACE.FCHPT |
| language | English |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| record_format | dspace |
| spelling | oai:localhost:123456789-1382021-04-07T16:30:08Z The epidemiology and aetiology of diarrhoeal disease in infancy in southern Vietnam: a birth cohort study Simmons, Cameron OBJECTIVES: Previous studies indicate a high burden of diarrhoeal disease in Vietnamese children, however longitudinal community-based data on burden and aetiology are limited. The findings from a large, prospective cohort study of diarrhoeal disease in infants in southern Vietnam are presented herein. METHODS: Infants were enrolled at birth in urban Ho Chi Minh City and a semi-rural district in southern Vietnam, and followed for 12 months (n=6706). Diarrhoeal illness episodes were identified through clinic-based passive surveillance, hospital admissions, and self-reports. RESULTS: The minimum incidence of diarrhoeal illness in the first year of life was 271/1000 infant-years of observation for the whole cohort. Rotavirus was the most commonly detected pathogen (50% of positive samples), followed by norovirus (24%), Campylobacter (20%), Salmonella (18%), and Shigella (16%). Repeat infections were identified in 9% of infants infected with rotavirus, norovirus, Shigella, or Campylobacter, and 13% of those with Salmonella infections. CONCLUSIONS: The minimum incidence of diarrhoeal disease in infants in both urban and semi-rural settings in southern Vietnam was quantified prospectively. A large proportion of laboratory-diagnosed disease was caused by rotavirus and norovirus. These data highlight the unmet need for a rotavirus vaccine in Vietnam and provide evidence of the previously unrecognized burden of norovirus in infants. 2018-09-14T11:14:58Z 2017-07-12T03:21:50Z 2018-09-14T11:14:58Z 2015-03-17 2015-03-17 2015-03-17 2015-03-17 2015-03-17 2015-03-17 2015-03-17 2015-03-17 2015-06-01 Journal Article https://demo7.dspace.org/handle/123456789/138 English |
| spellingShingle | Simmons, Cameron The epidemiology and aetiology of diarrhoeal disease in infancy in southern Vietnam: a birth cohort study |
| title | The epidemiology and aetiology of diarrhoeal disease in infancy in southern Vietnam: a birth cohort study |
| title_full | The epidemiology and aetiology of diarrhoeal disease in infancy in southern Vietnam: a birth cohort study |
| title_fullStr | The epidemiology and aetiology of diarrhoeal disease in infancy in southern Vietnam: a birth cohort study |
| title_full_unstemmed | The epidemiology and aetiology of diarrhoeal disease in infancy in southern Vietnam: a birth cohort study |
| title_short | The epidemiology and aetiology of diarrhoeal disease in infancy in southern Vietnam: a birth cohort study |
| title_sort | epidemiology and aetiology of diarrhoeal disease in infancy in southern vietnam a birth cohort study |
| url | https://demo7.dspace.org/handle/123456789/138 |
| work_keys_str_mv | AT simmonscameron theepidemiologyandaetiologyofdiarrhoealdiseaseininfancyinsouthernvietnamabirthcohortstudy AT simmonscameron epidemiologyandaetiologyofdiarrhoealdiseaseininfancyinsouthernvietnamabirthcohortstudy |