Dengue Human Infection Models Supporting Drug Development
Dengue is a arboviral infection that represents a major global health burden. There is an unmet need for effective dengue therapeutics to reduce symptoms, duration of illness and incidence of severe complications. Here, we consider the merits of a dengue human infection model (DHIM) for drug develop...
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| Autori principali: | , , , , |
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| Natura: | Journal Article |
| Lingua: | inglese |
| Pubblicazione: |
2018
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| Accesso online: | https://demo7.dspace.org/handle/123456789/160 |
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| _version_ | 1860822454826434560 |
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| author | Plain text author Plain text author 2 Eens, Marcel Vercauteren, Marcel Simmons, Cameron |
| author_browse | Eens, Marcel Plain text author Plain text author 2 Simmons, Cameron Vercauteren, Marcel |
| author_facet | Plain text author Plain text author 2 Eens, Marcel Vercauteren, Marcel Simmons, Cameron |
| author_sort | Plain text author |
| collection | DSpace |
| description | Dengue is a arboviral infection that represents a major global health burden. There is an unmet need for effective dengue therapeutics to reduce symptoms, duration of illness and incidence of severe complications. Here, we consider the merits of a dengue human infection model (DHIM) for drug development. A DHIM could allow experimentally controlled studies of candidate therapeutics in preselected susceptible volunteers, potentially using smaller sample sizes than trials that recruited patients with dengue in an endemic country. In addition, the DHIM would assist the conduct of intensive pharmacokinetic and basic research investigations and aid in determining optimal drug dosage. Furthermore, a DHIM could help establish proof of concept that chemoprophylaxis against dengue is feasible. The key challenge in developing the DHIM for drug development is to ensure the model reliably replicates the typical clinical and laboratory features of naturally acquired, symptomatic dengue. |
| format | Journal Article |
| id | oai:localhost:123456789-160 |
| institution | DSPACE.FCHPT |
| language | English |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| record_format | dspace |
| spelling | oai:localhost:123456789-1602021-04-07T16:30:08Z Dengue Human Infection Models Supporting Drug Development Plain text author Plain text author 2 Eens, Marcel Vercauteren, Marcel Simmons, Cameron Dengue is a arboviral infection that represents a major global health burden. There is an unmet need for effective dengue therapeutics to reduce symptoms, duration of illness and incidence of severe complications. Here, we consider the merits of a dengue human infection model (DHIM) for drug development. A DHIM could allow experimentally controlled studies of candidate therapeutics in preselected susceptible volunteers, potentially using smaller sample sizes than trials that recruited patients with dengue in an endemic country. In addition, the DHIM would assist the conduct of intensive pharmacokinetic and basic research investigations and aid in determining optimal drug dosage. Furthermore, a DHIM could help establish proof of concept that chemoprophylaxis against dengue is feasible. The key challenge in developing the DHIM for drug development is to ensure the model reliably replicates the typical clinical and laboratory features of naturally acquired, symptomatic dengue. 2018-09-14T11:15:01Z 2015-11-24T00:37:45Z 2018-09-14T11:15:01Z 2014-06-15 Journal Article https://demo7.dspace.org/handle/123456789/160 English |
| spellingShingle | Plain text author Plain text author 2 Eens, Marcel Vercauteren, Marcel Simmons, Cameron Dengue Human Infection Models Supporting Drug Development |
| title | Dengue Human Infection Models Supporting Drug Development |
| title_full | Dengue Human Infection Models Supporting Drug Development |
| title_fullStr | Dengue Human Infection Models Supporting Drug Development |
| title_full_unstemmed | Dengue Human Infection Models Supporting Drug Development |
| title_short | Dengue Human Infection Models Supporting Drug Development |
| title_sort | dengue human infection models supporting drug development |
| url | https://demo7.dspace.org/handle/123456789/160 |
| work_keys_str_mv | AT plaintextauthor denguehumaninfectionmodelssupportingdrugdevelopment AT plaintextauthor2 denguehumaninfectionmodelssupportingdrugdevelopment AT eensmarcel denguehumaninfectionmodelssupportingdrugdevelopment AT vercauterenmarcel denguehumaninfectionmodelssupportingdrugdevelopment AT simmonscameron denguehumaninfectionmodelssupportingdrugdevelopment |