Corticosteroids for Dengue - Why Don't They Work?
BACKGROUND: Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue. FINDINGS: In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in...
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| Format: | Journal Article |
| Langue: | anglais |
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2018
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| Accès en ligne: | https://demo7.dspace.org/handle/123456789/197 |
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| _version_ | 1860822453126692864 |
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| author | Simmons, Cameron |
| author_browse | Simmons, Cameron |
| author_facet | Simmons, Cameron |
| author_sort | Simmons, Cameron |
| collection | DSpace |
| description | BACKGROUND: Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue. FINDINGS: In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in whole-blood between high-dose (2 mg/kg) prednisolone and placebo-treated patients two days after commencing therapy. Prominent among the 81 transcripts were those associated with T and NK cell cytolytic functions. Additionally, prednisolone therapy was not associated with changes in plasma cytokine levels. CONCLUSION: The inability of prednisolone treatment to markedly attenuate the host immune response is instructive for planning future therapeutic strategies for dengue. |
| format | Journal Article |
| id | oai:localhost:123456789-197 |
| institution | DSPACE.FCHPT |
| language | English |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| record_format | dspace |
| spelling | oai:localhost:123456789-1972021-04-07T16:30:08Z Corticosteroids for Dengue - Why Don't They Work? Simmons, Cameron BACKGROUND: Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue. FINDINGS: In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in whole-blood between high-dose (2 mg/kg) prednisolone and placebo-treated patients two days after commencing therapy. Prominent among the 81 transcripts were those associated with T and NK cell cytolytic functions. Additionally, prednisolone therapy was not associated with changes in plasma cytokine levels. CONCLUSION: The inability of prednisolone treatment to markedly attenuate the host immune response is instructive for planning future therapeutic strategies for dengue. 2018-09-14T11:15:06Z 2017-07-12T03:36:54Z 2018-09-14T11:15:06Z 2013-10-31 2013-10-31 2013-10-31 2013-10-31 2013-10-31 2013-10-31 2013-10-31 2013-10-31 2013-12-01 Journal Article https://demo7.dspace.org/handle/123456789/197 English |
| spellingShingle | Simmons, Cameron Corticosteroids for Dengue - Why Don't They Work? |
| title | Corticosteroids for Dengue - Why Don't They Work? |
| title_full | Corticosteroids for Dengue - Why Don't They Work? |
| title_fullStr | Corticosteroids for Dengue - Why Don't They Work? |
| title_full_unstemmed | Corticosteroids for Dengue - Why Don't They Work? |
| title_short | Corticosteroids for Dengue - Why Don't They Work? |
| title_sort | corticosteroids for dengue why don t they work |
| url | https://demo7.dspace.org/handle/123456789/197 |
| work_keys_str_mv | AT simmonscameron corticosteroidsfordenguewhydonttheywork |