Immunomodulation using bacterialeEnterotoxins
Immunologic unresponsiveness (tolerance) is a key feature of the mucosal immune system, and deliberate vaccination by a mucosal route can effectively induce immune suppression. However, some bacterial-derived proteins, e.g. cholera toxin and the heat labile toxin of Escherichia coli, are immunogenic...
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| Format: | Journal Article |
| Language: | English |
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2018
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| Online Access: | https://demo7.dspace.org/handle/123456789/199 |
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| _version_ | 1860822454807560192 |
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| author | Simmons, Cameron |
| author_browse | Simmons, Cameron |
| author_facet | Simmons, Cameron |
| author_sort | Simmons, Cameron |
| collection | DSpace |
| description | Immunologic unresponsiveness (tolerance) is a key feature of the mucosal immune system, and deliberate vaccination by a mucosal route can effectively induce immune suppression. However, some bacterial-derived proteins, e.g. cholera toxin and the heat labile toxin of Escherichia coli, are immunogenic and immunomodulatory at mucosal surfaces and can effectively adjuvant immune responses to codelivered bystander antigens. This review summarizes some of the structural and biological characteristics of these toxins and provides examples of how these properties have been exploited for tolerance induction and mucosal vaccine development. |
| format | Journal Article |
| id | oai:localhost:123456789-199 |
| institution | DSPACE.FCHPT |
| language | English |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| record_format | dspace |
| spelling | oai:localhost:123456789-1992021-04-07T16:30:08Z Immunomodulation using bacterialeEnterotoxins Simmons, Cameron Immunologic unresponsiveness (tolerance) is a key feature of the mucosal immune system, and deliberate vaccination by a mucosal route can effectively induce immune suppression. However, some bacterial-derived proteins, e.g. cholera toxin and the heat labile toxin of Escherichia coli, are immunogenic and immunomodulatory at mucosal surfaces and can effectively adjuvant immune responses to codelivered bystander antigens. This review summarizes some of the structural and biological characteristics of these toxins and provides examples of how these properties have been exploited for tolerance induction and mucosal vaccine development. 2018-09-14T11:15:06Z 2017-07-05T04:39:18Z 2018-09-14T11:15:06Z 2001-03-01 Journal Article https://demo7.dspace.org/handle/123456789/199 English |
| spellingShingle | Simmons, Cameron Immunomodulation using bacterialeEnterotoxins |
| title | Immunomodulation using bacterialeEnterotoxins |
| title_full | Immunomodulation using bacterialeEnterotoxins |
| title_fullStr | Immunomodulation using bacterialeEnterotoxins |
| title_full_unstemmed | Immunomodulation using bacterialeEnterotoxins |
| title_short | Immunomodulation using bacterialeEnterotoxins |
| title_sort | immunomodulation using bacterialeenterotoxins |
| url | https://demo7.dspace.org/handle/123456789/199 |
| work_keys_str_mv | AT simmonscameron immunomodulationusingbacterialeenterotoxins |