Age- and tumor subtype-specific breast cancer risk estimates for CHEK2*1100delC carriers
CHEK2*1100delC is a well-established breast cancer risk variant, most prevalent in European populations. However, there are limited data on risk of breast cancer by age and tumor subtype, limiting its usefulness in breast cancer risk prediction. We aimed to generate tumor subtype- and age-specific r...
Salvato in:
| Autori principali: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Altri autori: | |
| Lingua: | inglese |
| Pubblicazione: |
American Society of Clinical Oncology
2019
|
| Accesso online: | https://demo7.dspace.org/handle/123456789/442 |
| Tags: |
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
| _version_ | 1860822454779248640 |
|---|---|
| author | Schmidt, Marjanka K Hogervorst, Frans van, Hien Richard Cornelissen, Sten Broeks, Annegien Adank, Muriel Meijers, Hanne Waisfisz, Quinten Hollestelle, Antoinette Schutte, Mieke van, den Ouweland Ans Hooning, Maartje Andrulis, Irene L Anton-Culver, Hoda Antonenkova, Natalia N Antoniou, Antonis Arndt, Volker Bermisheva, Marina Bogdanova, Natalia V Bolla, Manjeet K Brauch, Hiltrud Brenner, Hermann Brüning, Thomas Burwinkel, Barbara Chang-Claude, Jenny Chenevix-Trench, Georgia Couch, Fergus J Cox, Angela Cross, Simon S Czene, Kamila Dunning, Alison Fasching, Peter A Figueroa, Jonine Fletcher, Olivia Flyger, Henrik Galle, Eva García-Closas, Montserrat Giles, Graham G Haeberle, Lothar Hall, Per Hillemanns, Peter Hopper, John L Jakubowska, Anna John, Esther M Jones, Michael Khusnutdinova, Elza Knight, Julia A Kosma, Veli-Matti Kristensen, Vessela Lee, Andrew Lindblom, Annika Lubinski, Jan Mannermaa, Arto Margolin, Sara Meindl, Alfons Milne, Roger L Muranen, Taru A NBCS, Investigators Newcomb, Polly A Offitt, Kenneth Park-Simon, Tjoung-Won Peto, Julian Pharoah, Paul Robson, Mark Rudolph, Anja Sawyer, Elinor J Schmutzler, Rita K Seynaeve, Caroline Soens, Julie Southey, Melissa C Spurdle, Amanda Surowy, Harald Swerdlow, Anthony Tollenaar, Rob AEM Tomlinson, Ian Trentham-Dietz, Amy Vachon, Celine Wang, Qin Whittemore, Alice S Ziogas, Argyrios van, der Kolk Lizet Nevanlinna, Heli Dörk, Thilo Bojesen, Stig Easton, Douglas |
| author2 | Law Enforcement |
| author_browse | Adank, Muriel Andrulis, Irene L Anton-Culver, Hoda Antonenkova, Natalia N Antoniou, Antonis Arndt, Volker Bermisheva, Marina Bogdanova, Natalia V Bojesen, Stig Bolla, Manjeet K Brauch, Hiltrud Brenner, Hermann Broeks, Annegien Brüning, Thomas Burwinkel, Barbara Chang-Claude, Jenny Chenevix-Trench, Georgia Cornelissen, Sten Couch, Fergus J Cox, Angela Cross, Simon S Czene, Kamila Dunning, Alison Dörk, Thilo Easton, Douglas Fasching, Peter A Figueroa, Jonine Fletcher, Olivia Flyger, Henrik Galle, Eva García-Closas, Montserrat Giles, Graham G Haeberle, Lothar Hall, Per Hillemanns, Peter Hogervorst, Frans Hollestelle, Antoinette Hooning, Maartje Hopper, John L Jakubowska, Anna John, Esther M Jones, Michael Khusnutdinova, Elza Knight, Julia A Kosma, Veli-Matti Kristensen, Vessela Law Enforcement Lee, Andrew Lindblom, Annika Lubinski, Jan Mannermaa, Arto Margolin, Sara Meijers, Hanne Meindl, Alfons Milne, Roger L Muranen, Taru A NBCS, Investigators Nevanlinna, Heli Newcomb, Polly A Offitt, Kenneth Park-Simon, Tjoung-Won Peto, Julian Pharoah, Paul Robson, Mark Rudolph, Anja Sawyer, Elinor J Schmidt, Marjanka K Schmutzler, Rita K Schutte, Mieke Seynaeve, Caroline Soens, Julie Southey, Melissa C Spurdle, Amanda Surowy, Harald Swerdlow, Anthony Tollenaar, Rob AEM Tomlinson, Ian Trentham-Dietz, Amy Vachon, Celine Waisfisz, Quinten Wang, Qin Whittemore, Alice S Ziogas, Argyrios van, Hien Richard van, den Ouweland Ans van, der Kolk Lizet |
| author_facet | Law Enforcement Schmidt, Marjanka K Hogervorst, Frans van, Hien Richard Cornelissen, Sten Broeks, Annegien Adank, Muriel Meijers, Hanne Waisfisz, Quinten Hollestelle, Antoinette Schutte, Mieke van, den Ouweland Ans Hooning, Maartje Andrulis, Irene L Anton-Culver, Hoda Antonenkova, Natalia N Antoniou, Antonis Arndt, Volker Bermisheva, Marina Bogdanova, Natalia V Bolla, Manjeet K Brauch, Hiltrud Brenner, Hermann Brüning, Thomas Burwinkel, Barbara Chang-Claude, Jenny Chenevix-Trench, Georgia Couch, Fergus J Cox, Angela Cross, Simon S Czene, Kamila Dunning, Alison Fasching, Peter A Figueroa, Jonine Fletcher, Olivia Flyger, Henrik Galle, Eva García-Closas, Montserrat Giles, Graham G Haeberle, Lothar Hall, Per Hillemanns, Peter Hopper, John L Jakubowska, Anna John, Esther M Jones, Michael Khusnutdinova, Elza Knight, Julia A Kosma, Veli-Matti Kristensen, Vessela Lee, Andrew Lindblom, Annika Lubinski, Jan Mannermaa, Arto Margolin, Sara Meindl, Alfons Milne, Roger L Muranen, Taru A NBCS, Investigators Newcomb, Polly A Offitt, Kenneth Park-Simon, Tjoung-Won Peto, Julian Pharoah, Paul Robson, Mark Rudolph, Anja Sawyer, Elinor J Schmutzler, Rita K Seynaeve, Caroline Soens, Julie Southey, Melissa C Spurdle, Amanda Surowy, Harald Swerdlow, Anthony Tollenaar, Rob AEM Tomlinson, Ian Trentham-Dietz, Amy Vachon, Celine Wang, Qin Whittemore, Alice S Ziogas, Argyrios van, der Kolk Lizet Nevanlinna, Heli Dörk, Thilo Bojesen, Stig Easton, Douglas |
| author_sort | Schmidt, Marjanka K |
| collection | DSpace |
| description | CHEK2*1100delC is a well-established breast cancer risk variant, most prevalent in European populations. However, there are limited data on risk of breast cancer by age and tumor subtype, limiting its usefulness in breast cancer risk prediction. We aimed to generate tumor subtype- and age-specific risk estimates using data from the Breast Cancer Association Consortium, including 44,777 breast cancer patients and 42,997 controls from 33 studies genotyped for CHEK2*1100delC. CHEK2*1100delC genotyping was mostly done by a custom Taqman assay. Breast cancer odds ratios (OR) for CHEK2*1100delC carriers versus non-carriers were estimated using logistic regression; adjusting for study (categorical) and age. Main analyses included invasive breast cancer patients from population- and hospital-based studies. The proportions of heterozygous CHEK2*1100delC carriers in controls, in breast cancer patients from population- and hospital-based studies, and in breast cancer patients from familial and clinical genetics center-based studies, were 0.5%, 1.3%, and 3.0% respectively. The estimated OR f or invasive breast cancer was 2.26 (95%CI:1.90-2.69; p=2.3x10^-20). The OR was higher f or estrogen receptor (ER)-positive disease 2.55 (95%CI:2.10-3.10; p=4.9x10^-21) than for ER-negative disease 1.32 (95%CI: 0.93-1.88; p=0.12) (p interaction=9.9x10^-4). The OR significantly declined with attained age for breast cancer overall (p=0.001) and for ER-positive tumors (p=0.001). Estimated cumulative risks for CHEK2*1100delC carriers for the development of ER-positive and ER-negative tumors by age 80 were respectively 20% and 3%, compared with 9% and 2% in the UK general population. These CHEK2*1100delC breast cancer risk estimates provide a basis for incorporating CHEK2*1100delC into breast cancer risk prediction models, and into guidelines for intensified screening and follow-up. |
| id | oai:localhost:123456789-442 |
| institution | DSPACE.FCHPT |
| language | English |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | American Society of Clinical Oncology |
| publisherStr | American Society of Clinical Oncology |
| record_format | dspace |
| spelling | oai:localhost:123456789-4422021-04-07T16:30:12Z Age- and tumor subtype-specific breast cancer risk estimates for CHEK2*1100delC carriers Schmidt, Marjanka K Hogervorst, Frans van, Hien Richard Cornelissen, Sten Broeks, Annegien Adank, Muriel Meijers, Hanne Waisfisz, Quinten Hollestelle, Antoinette Schutte, Mieke van, den Ouweland Ans Hooning, Maartje Andrulis, Irene L Anton-Culver, Hoda Antonenkova, Natalia N Antoniou, Antonis Arndt, Volker Bermisheva, Marina Bogdanova, Natalia V Bolla, Manjeet K Brauch, Hiltrud Brenner, Hermann Brüning, Thomas Burwinkel, Barbara Chang-Claude, Jenny Chenevix-Trench, Georgia Couch, Fergus J Cox, Angela Cross, Simon S Czene, Kamila Dunning, Alison Fasching, Peter A Figueroa, Jonine Fletcher, Olivia Flyger, Henrik Galle, Eva García-Closas, Montserrat Giles, Graham G Haeberle, Lothar Hall, Per Hillemanns, Peter Hopper, John L Jakubowska, Anna John, Esther M Jones, Michael Khusnutdinova, Elza Knight, Julia A Kosma, Veli-Matti Kristensen, Vessela Lee, Andrew Lindblom, Annika Lubinski, Jan Mannermaa, Arto Margolin, Sara Meindl, Alfons Milne, Roger L Muranen, Taru A NBCS, Investigators Newcomb, Polly A Offitt, Kenneth Park-Simon, Tjoung-Won Peto, Julian Pharoah, Paul Robson, Mark Rudolph, Anja Sawyer, Elinor J Schmutzler, Rita K Seynaeve, Caroline Soens, Julie Southey, Melissa C Spurdle, Amanda Surowy, Harald Swerdlow, Anthony Tollenaar, Rob AEM Tomlinson, Ian Trentham-Dietz, Amy Vachon, Celine Wang, Qin Whittemore, Alice S Ziogas, Argyrios van, der Kolk Lizet Nevanlinna, Heli Dörk, Thilo Bojesen, Stig Easton, Douglas Law Enforcement Law and Development Personal Rights & Property Rights Government & Law Business & Law CHEK2*1100delC is a well-established breast cancer risk variant, most prevalent in European populations. However, there are limited data on risk of breast cancer by age and tumor subtype, limiting its usefulness in breast cancer risk prediction. We aimed to generate tumor subtype- and age-specific risk estimates using data from the Breast Cancer Association Consortium, including 44,777 breast cancer patients and 42,997 controls from 33 studies genotyped for CHEK2*1100delC. CHEK2*1100delC genotyping was mostly done by a custom Taqman assay. Breast cancer odds ratios (OR) for CHEK2*1100delC carriers versus non-carriers were estimated using logistic regression; adjusting for study (categorical) and age. Main analyses included invasive breast cancer patients from population- and hospital-based studies. The proportions of heterozygous CHEK2*1100delC carriers in controls, in breast cancer patients from population- and hospital-based studies, and in breast cancer patients from familial and clinical genetics center-based studies, were 0.5%, 1.3%, and 3.0% respectively. The estimated OR f or invasive breast cancer was 2.26 (95%CI:1.90-2.69; p=2.3x10^-20). The OR was higher f or estrogen receptor (ER)-positive disease 2.55 (95%CI:2.10-3.10; p=4.9x10^-21) than for ER-negative disease 1.32 (95%CI: 0.93-1.88; p=0.12) (p interaction=9.9x10^-4). The OR significantly declined with attained age for breast cancer overall (p=0.001) and for ER-positive tumors (p=0.001). Estimated cumulative risks for CHEK2*1100delC carriers for the development of ER-positive and ER-negative tumors by age 80 were respectively 20% and 3%, compared with 9% and 2% in the UK general population. These CHEK2*1100delC breast cancer risk estimates provide a basis for incorporating CHEK2*1100delC into breast cancer risk prediction models, and into guidelines for intensified screening and follow-up. 2019-04-26T08:57:00Z 2019-04-26T08:57:00Z 2016 https://demo7.dspace.org/handle/123456789/442 en American Society of Clinical Oncology |
| spellingShingle | Schmidt, Marjanka K Hogervorst, Frans van, Hien Richard Cornelissen, Sten Broeks, Annegien Adank, Muriel Meijers, Hanne Waisfisz, Quinten Hollestelle, Antoinette Schutte, Mieke van, den Ouweland Ans Hooning, Maartje Andrulis, Irene L Anton-Culver, Hoda Antonenkova, Natalia N Antoniou, Antonis Arndt, Volker Bermisheva, Marina Bogdanova, Natalia V Bolla, Manjeet K Brauch, Hiltrud Brenner, Hermann Brüning, Thomas Burwinkel, Barbara Chang-Claude, Jenny Chenevix-Trench, Georgia Couch, Fergus J Cox, Angela Cross, Simon S Czene, Kamila Dunning, Alison Fasching, Peter A Figueroa, Jonine Fletcher, Olivia Flyger, Henrik Galle, Eva García-Closas, Montserrat Giles, Graham G Haeberle, Lothar Hall, Per Hillemanns, Peter Hopper, John L Jakubowska, Anna John, Esther M Jones, Michael Khusnutdinova, Elza Knight, Julia A Kosma, Veli-Matti Kristensen, Vessela Lee, Andrew Lindblom, Annika Lubinski, Jan Mannermaa, Arto Margolin, Sara Meindl, Alfons Milne, Roger L Muranen, Taru A NBCS, Investigators Newcomb, Polly A Offitt, Kenneth Park-Simon, Tjoung-Won Peto, Julian Pharoah, Paul Robson, Mark Rudolph, Anja Sawyer, Elinor J Schmutzler, Rita K Seynaeve, Caroline Soens, Julie Southey, Melissa C Spurdle, Amanda Surowy, Harald Swerdlow, Anthony Tollenaar, Rob AEM Tomlinson, Ian Trentham-Dietz, Amy Vachon, Celine Wang, Qin Whittemore, Alice S Ziogas, Argyrios van, der Kolk Lizet Nevanlinna, Heli Dörk, Thilo Bojesen, Stig Easton, Douglas Age- and tumor subtype-specific breast cancer risk estimates for CHEK2*1100delC carriers |
| title | Age- and tumor subtype-specific breast cancer risk estimates for CHEK2*1100delC carriers |
| title_full | Age- and tumor subtype-specific breast cancer risk estimates for CHEK2*1100delC carriers |
| title_fullStr | Age- and tumor subtype-specific breast cancer risk estimates for CHEK2*1100delC carriers |
| title_full_unstemmed | Age- and tumor subtype-specific breast cancer risk estimates for CHEK2*1100delC carriers |
| title_short | Age- and tumor subtype-specific breast cancer risk estimates for CHEK2*1100delC carriers |
| title_sort | age and tumor subtype specific breast cancer risk estimates for chek2 1100delc carriers |
| url | https://demo7.dspace.org/handle/123456789/442 |
| work_keys_str_mv | AT schmidtmarjankak ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT hogervorstfrans ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT vanhienrichard ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT cornelissensten ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT broeksannegien ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT adankmuriel ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT meijershanne ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT waisfiszquinten ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT hollestelleantoinette ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT schuttemieke ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT vandenouwelandans ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT hooningmaartje ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT andrulisirenel ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT antonculverhoda ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT antonenkovanatalian ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT antoniouantonis ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT arndtvolker ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT bermishevamarina ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT bogdanovanataliav ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT bollamanjeetk ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT brauchhiltrud ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT brennerhermann ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT bruningthomas ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT burwinkelbarbara ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT changclaudejenny ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT chenevixtrenchgeorgia ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT couchfergusj ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT coxangela ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT crosssimons ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT czenekamila ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT dunningalison ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT faschingpetera ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT figueroajonine ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT fletcherolivia ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT flygerhenrik ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT galleeva ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT garciaclosasmontserrat ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT gilesgrahamg ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT haeberlelothar ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT hallper ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT hillemannspeter ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT hopperjohnl ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT jakubowskaanna ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT johnestherm ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT jonesmichael ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT khusnutdinovaelza ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT knightjuliaa ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT kosmavelimatti ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT kristensenvessela ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT leeandrew ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT lindblomannika ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT lubinskijan ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT mannermaaarto ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT margolinsara ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT meindlalfons ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT milnerogerl ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT muranentarua ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT nbcsinvestigators ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT newcombpollya ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT offittkenneth ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT parksimontjoungwon ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT petojulian ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT pharoahpaul ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT robsonmark ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT rudolphanja ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT sawyerelinorj ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT schmutzlerritak ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT seynaevecaroline ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT soensjulie ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT southeymelissac ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT spurdleamanda ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT surowyharald ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT swerdlowanthony ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT tollenaarrobaem ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT tomlinsonian ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT trenthamdietzamy ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT vachonceline ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT wangqin ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT whittemorealices ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT ziogasargyrios ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT vanderkolklizet ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT nevanlinnaheli ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT dorkthilo ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT bojesenstig ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers AT eastondouglas ageandtumorsubtypespecificbreastcancerriskestimatesforchek21100delccarriers |